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What is the best medication for high systolic blood pressure?

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How Is It Treated? Diuretics (water pills) to help your kidneys flush water and sodium from your body. Beta-blockers to make your heart beat slower and less forcefully. Angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), or calcium channel blockers to relax your blood vessels.
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